Hepatoprotective activity of Mammea africana ethanol stem bark extract

نویسندگان

  • Herbert Orji Mbagwu Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
  • Jude Efiom Okokon Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
  • Michael Burata Bawo Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
چکیده مقاله:

Mammea africana Sabine (Guttiferae) stembark, a common plant, traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol- induced liver injury in rats. The hepatoprotective effect of the stembark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters: total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and alkaline phosphatase activities (ALP), antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and histopathological study of the liver. The administration of the stembark extract caused significant (p

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منابع مشابه

Hepatoprotective activity of Mammea africana ethanol stem bark extract

OBJECTIVE The stem bark of Mammea africana Sabine (Guttiferae), (M. africana) a common plant that has been traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol-induced liver injury in rats. MATERIALS AND METHODS The hepatoprotective effect of the stem bark extract (30-90 mg/kg) was evaluated by the assay of liver function ...

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hepatoprotective activity of mammea africana ethanol stem bark extract

mammea africana sabine (guttiferae) stembark, a common plant, traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol- induced liver injury in rats. the hepatoprotective effect of the stembark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters: total and direct bilirubin, serum protein and albumin, to...

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Nephroprotective activity of Mammea africana stem bark against paracetamol induced kidney injury

Background & Aim: Mammea africana sabine (Guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. Experimental:  The nephroprotective effect of the extract was evaluated by the determination of some kidn...

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Nephroprotective activity of Mammea africana stem bark against paracetamol induced kidney injury

Background & Aim: Mammea africana sabine (Guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. Experimental:  The nephroprotective effect of the extract was evaluated by the determination of some kidn...

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nephroprotective activity of mammea africana stem bark against paracetamol induced kidney injury

background & aim: mammea africana sabine (guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. experimental:  the nephroprotective effect of the extract was evaluated by the determination of some kidney fun...

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Hepatoprotective properties of Bauhinia variegata bark extract.

Bauhinia variegata (Leguminosae) commonly known as Kachnar, is widely used in Ayurveda as tonic to the liver. The present work was carried out to assess the potential of Bauhinia variegata bark as hepatoprotective agent. The hepatoprotective activity was investigated in carbon tetrachloride (CCl(4)) intoxicated Sprague-Dawley rats. Bauhinia variegata alcoholic Stem Bark Extract (SBE) at differe...

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عنوان ژورنال

دوره 6  شماره 2

صفحات  248- 259

تاریخ انتشار 2016-03-01

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